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Image Search Results
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Article Title: A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria
doi: 10.1096/fj.202402274R
Figure Lengend Snippet: (A) PCR of genomic DNA from mice who produced NAP offspring and NAP offspring demonstrated Myo5a (c.1752g>a) in the heterozygous state in parents and in the homozygous state in NAP mice (NAP mice ( n= 8), parents ( n= 6)). Unaffected littermates were either heterozygous or wild type for Myo5a (c.1752g>a) ( n= 6). (B) LOD score calculations derived from genotypes determined from a mouse universal genotyping array are shown from chromosome 9. The position of the Myo5a (c.1752g>a) is indicated with the red line and yields a LOD score=3.52 ( n= 20 mice; 8 NAP, 6 parents, 2 MRL, 2 129, 2 B6). (C) Across 13 litters ( n= 95) NAP mice were born in the expected Mendelian ratio, indicating no significant prenatal loss ( P= 0.84, Chi-squared test). (D) Myo5a (c.1752g>a) maps to the 3’ boundary of Myo5a exon 14 (of 41 exons). (E) The position of Myo5a (c.1752g>a) (green arrow) is within the N-terminal, “head” region of MYO5A.
Article Snippet: A
Techniques: Variant Assay, Produced, Derivative Assay